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Sufferers with Renal Impairment There is no encounter with the use of Focalin XR in patients with renal impairment. Because renal clearance isn't a crucial route of methylphenidate elimination, renal impairment is anticipated to own minor effect on the pharmacokinetics of Focalin XR.Mutagenesis Dexmethylphenidate was not mutagenic in the in vitro A

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